Read e-book online ABC Transporters and Multidrug Resistance (Wiley Series in PDF

By Ahcene Boumendjel, Jean Boutonnat, Jacques Robert

ISBN-10: 0470227346

ISBN-13: 9780470227343

A accomplished overview of the most up-tp-date medical examine on ABC transporters and multidrug resistanceATP-binding cassette transporter genes (ABC transporters) are identified to play a vital function within the improvement of multidrug resistance (MDR). MDR is the facility of pathologic cells, similar to tumors, to resist chemical compounds designed to focus on and smash such cells. In MDR, sufferers who're on drugs finally increase resistance not to purely the drug they're taking, yet to numerous varieties of drugs.ABC Transporters and Multidrug Resistance bargains a vital source for pharmaceutical researchers who're operating to find medicinal drugs to counteract multidrug resistance in ailments resembling melanoma. in a single complete quantity, this ebook encompasses a number of the most up-tp-date wisdom at the involvement of ABC transporters in drug shipping and resistance.This finished quantity offers an outline at the description of the constitution, the genome, general tissue expression, physiological point, and mechanism of motion of the ABC protein. The professional members discover the expression, detection, and implications of ABC proteins in hematological malignancies and sturdy tumors and ABC proteins and pathogenic microorganisms. This quantity additionally explains MDR modulation via inhibition of ABC transporters and the layout of inhibitors and mechanism of motion. additionally, the ebook bargains crucial details at the organic and scientific point of multidrug resistance.

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Additional info for ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development)

Sample text

1987. Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci U S A 84: 265–269. 91. Fromm MF. 2003. Importance of P-glycoprotein for drug disposition in humans. Eur J Clin Invest 33: 6–9. 92. Thuerauf N and Fromm MF. 2006. The role of the transporter P-glycoprotein for disposition and effects of centrally acting drugs and for the pathogenesis of CNS diseases. Eur Arch Psychiatry Clin Neurosci 256: 281–286. 93. Konishi T, Satsu H, Hatsugai Y, Aizawa K, Inakuma T, Nagata S et al.

3. Control and Regulation of Apoptosis A growing number of publications debate about the role of P-gp in apoptosis (164). Of course, due to its drug efflux function, P-gp exerts a strong downregulatory effect on drug-induced cell death, but it seems that this prevention 34 THE P-GLYCOPROTEIN 170 is not limited to this mechanism. Several works reported that P-gp might play a role in regulation of cell death against different stimuli. Robinson et al. (165) showed that P-gp overexpression was associated with resistance to serum starvation-induced apoptosis in Chinese hamster ovary fibroblasts and that the resistance was reversed by verapamil, indicating that P-gp was required for this resistance.

Loo TW and Clarke DM. 2005. Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux. J Membr Biol 206: 173–185. 9. Vaalburg W, Hendrikse NH, Elsinga PH, Bart J, and van Waarde A. 2005. P-glycoprotein activity and biological response. Toxicol Appl Pharmacol 207: 257–260. 10. Chinn LW and Kroetz DL. 2007. ABCB1 pharmacogenetics: Progress, pitfalls, and promise. Clin Pharmacol Ther 81: 265–269. 11. Hennessy M and Spiers JP. 2007. A primer on the mechanics of P-glycoprotein the multidrug transporter.

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ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development) by Ahcene Boumendjel, Jean Boutonnat, Jacques Robert


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