Advances in Enzymology and Related Areas of Molecular - download pdf or read online

By Alton Meister

ISBN-10: 0470123087

ISBN-13: 9780470123089

ISBN-10: 0471617709

ISBN-13: 9780471617709

Ribonuclease P: An Enzyme with a Catalytic RNA Subunit (S. Altman).

legislation of Escherichia coli Glutamine Synthetase (S. Rhee, et al.).

Glucose 6-Phosphatase: strategies of Membrane-Function courting (K. Sukalski & R. Nordlie).

Chiral Phosphorothioates: Stereochemical research of Enzymatic Substitution at Phosphorus (P. Frey).

Serotonin and Peptide Immunoneuromodulators: contemporary Discoveries and New rules (D. Silverman & M. Karnovsky).

The Phosphyglycerate Mutases (L. Fothergill-Gilmore & H. Watson).

Mechanism and law of the Glutamine-Dependent Carbamyl Phosphate Synthetase of Escherichia coli (A. Meister).

writer Index.

topic Index.

Cummulative Index, Vols.

1-62.Content:

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Extra resources for Advances in Enzymology and Related Areas of Molecular Biology, Volume 62

Sample text

11. Molecular Properties of Glutamine Synthetase Escherichiu coli GS exists as a dodecamer of 12 identical subunits. Each subunit contains 468 amino acid residues and has a molecular weight of 51,814 Da (1 1). Like the GS from other enteric bacteria, the E. coli enzyme can undergo covalent interconversion, adenylylation, and deadenylylation. This covalent modification, which will be discussed later, is the basis of an elegant regulatory mechanism for both the enzymic activity and the biosynthesis of the enzyme.

19. , J. Biol. Chem. 255, 7507 (1980). 20. , Proc. Natl. Acad. Sci. USA 76, 3795 (1979). 21. , Cell 19, 881 (1980). 21a. , and Altman, S . , Biochem. 20, 1902 (1981). 22. , Proc. Natl. Acad. Sci. USA 76, 5495 (1979). 23. , Cell 30,627 (1982). 24. , Cell 45, 177 (1986). 25. ,J . Biol. Chem. 263, 2344 (1988). 26. , and Bruening, G . , Proc. Natl. Acad. Sci. USA 83, 8859 (1986). 27. , Nature 323, 349 (1986). RIBONUCLEASE P 35 28. , Nucleic Acids Res. 14, 3627 (1986). 29. , Cell 48, 535 (1987). 30.

In the extended active site which includes the guide sequence, at least some of the noncovalent interactions are arranged in a regular array along the substrate and enzyme. Proof of the importance of guide sequences comes from experiments in which single nucleotides are changed to interfere with the base-pairing. Catalytic efficiency can be reduced by such changes but can be restored by restoration of the base pair. There is no evidence yet that such extended sequences play a role in the other reactions shown in Table 1.

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Advances in Enzymology and Related Areas of Molecular Biology, Volume 62 by Alton Meister


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