By Alton Meister
Ribonuclease P: An Enzyme with a Catalytic RNA Subunit (S. Altman).
legislation of Escherichia coli Glutamine Synthetase (S. Rhee, et al.).
Glucose 6-Phosphatase: strategies of Membrane-Function courting (K. Sukalski & R. Nordlie).
Chiral Phosphorothioates: Stereochemical research of Enzymatic Substitution at Phosphorus (P. Frey).
Serotonin and Peptide Immunoneuromodulators: contemporary Discoveries and New rules (D. Silverman & M. Karnovsky).
The Phosphyglycerate Mutases (L. Fothergill-Gilmore & H. Watson).
Mechanism and law of the Glutamine-Dependent Carbamyl Phosphate Synthetase of Escherichia coli (A. Meister).
Cummulative Index, Vols.
Read or Download Advances in Enzymology and Related Areas of Molecular Biology, Volume 62 PDF
Similar molecular biology books
Ubiquitin-proteasome-dependent proteolysis is relevant to a huge multitude of approaches in all eukaryotes, together with the cellphone cycle, cellphone progress and differentiation, embryogenesis, apoptosis, sign transduction, DNA fix, rules of transcription and DNA replication, transmembrane delivery, endocytosis, rigidity responses, antigen presentation and different facets of the immune reaction, the services of the worried method together with circadian rhythms, axon tips and acquisition of reminiscence.
This quantity seriously examines the practical activities of the kainate‑type glutamate receptors (KARs). Following on from the bigger physique of labor at the NMDA‑ and AMPA-type ionotropic glutamate receptors (GluRs), reports with KARs have regularly thrown up exceptions to common ideas approximately synaptic modulation.
Scientific functions for subsequent iteration Sequencing offers readers with a great postgraduate source to benefit in regards to the translational use of NGS in scientific environments. Rooted in either scientific genetics and scientific drugs, the e-book fills the distance among state of the art expertise and evidence-based perform, delivering an instructional chance for clients to boost sufferer care via moving NGS to the desires of real-world sufferers.
Providing state of the art protocols to check hole junctions, this designated publication first makes a speciality of using tools and instruments to enquire different features of connexin expression and hole junction rules. the second one a part of the amount describes numerous ways to probe hole junction performance as such.
- Advances in Enzymology and Related Areas of Molecular Biology, Volume 4
- Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications
- Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease
- Mass Spectrometry: Modified Proteins and Glycoconjugates
Extra resources for Advances in Enzymology and Related Areas of Molecular Biology, Volume 62
11. Molecular Properties of Glutamine Synthetase Escherichiu coli GS exists as a dodecamer of 12 identical subunits. Each subunit contains 468 amino acid residues and has a molecular weight of 51,814 Da (1 1). Like the GS from other enteric bacteria, the E. coli enzyme can undergo covalent interconversion, adenylylation, and deadenylylation. This covalent modification, which will be discussed later, is the basis of an elegant regulatory mechanism for both the enzymic activity and the biosynthesis of the enzyme.
19. , J. Biol. Chem. 255, 7507 (1980). 20. , Proc. Natl. Acad. Sci. USA 76, 3795 (1979). 21. , Cell 19, 881 (1980). 21a. , and Altman, S . , Biochem. 20, 1902 (1981). 22. , Proc. Natl. Acad. Sci. USA 76, 5495 (1979). 23. , Cell 30,627 (1982). 24. , Cell 45, 177 (1986). 25. ,J . Biol. Chem. 263, 2344 (1988). 26. , and Bruening, G . , Proc. Natl. Acad. Sci. USA 83, 8859 (1986). 27. , Nature 323, 349 (1986). RIBONUCLEASE P 35 28. , Nucleic Acids Res. 14, 3627 (1986). 29. , Cell 48, 535 (1987). 30.
In the extended active site which includes the guide sequence, at least some of the noncovalent interactions are arranged in a regular array along the substrate and enzyme. Proof of the importance of guide sequences comes from experiments in which single nucleotides are changed to interfere with the base-pairing. Catalytic efficiency can be reduced by such changes but can be restored by restoration of the base pair. There is no evidence yet that such extended sequences play a role in the other reactions shown in Table 1.
Advances in Enzymology and Related Areas of Molecular Biology, Volume 62 by Alton Meister