By Kjell Öberg, Gunnar Alm (auth.), Huub Schellekens (eds.)
This publication, written by way of prime authors within the box, is the 1st to house all facets of cytokine antibodies, from try out technique and standardization to organic outcomes and features. It encompasses antibodies brought on through cytokines used therapeutically and antiviral antibodies. to appreciate the biology, the results of cytokine antibodies in experimental animal types and sufferers also are mentioned. The e-book is meant for researchers of cytokine biology, pharmaceutical businesses constructing cytokines and cytokine antibodies as cures, and clinicians attracted to modulating the immune procedure as therapy.
Read Online or Download Antibodies in Cytokines: The concerted action on the antigenicity of rDNA derived pharmaceuticals PDF
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Additional resources for Antibodies in Cytokines: The concerted action on the antigenicity of rDNA derived pharmaceuticals
The appearance of IFN bioactivity was associated with a rapid loss in animal weight and approximately one week after the detection of IFN bioactivity in the circulation, the animals suffered from general malaise and died from an as yet unknown cause. The analysis of serum prepared from blood taken just prior to death demonstrated that the IFN bioactivity was not retained by a column with immobilized protein A, indicating that the IFN was not complexed with circulating antibodies. Since recombinant rat IFN-,8 is very rapidly cleared from the circulation (six hours after intravenous injection, less than I % of the antiviral bioactivity is recovered from the serum; unpublished observations), it is unlikely that the IFN bioactivity originated from the administered rat IFN-,8.
As they can interfere only with the immunomodulating activities of IFN-')', these antibodies might open up new therapeutic approaches to diseases with evidence of activated cell-mediated immunity. Detection of antibodies to human IFN-')'. Interferon (IFN)-')' is a glycoprotein of 143 amino acids produced by T lymphocytes and natural killer cells in response to mitogenic or antigenic stimuli, and is associated with potent antiviral, antiproliferative and immunomodulating functions. As a self-recognized substance, IFN-')' should not elicit antibodies in man since we reported the presence of high serum titres of IFN-')' antibodies in patients infected with human immunodeficiency virus (HIV) who had never received exogenous IFN-')' therapy, and also the surprising presence of weak but still detectable titres of IFN-')' antibodies in healthy individuals (Table 1).
On the other hand, IFN-,B augments this autoimmune disorder under conditions that peripheral activated inflammatory cells are able to penetrate the CNS. Previously, several mechanisms have been put forward to explain why type I IFNs adversely affect autoimmune reactions but none were substantiated with conclusive data (45,46). In particular, the direct effects oflFNs on B cell activation were thought to be important. However, a clear mechanism of how IFNs stimulate B cell activity and autoantibody production is still lacking.
Antibodies in Cytokines: The concerted action on the antigenicity of rDNA derived pharmaceuticals by Kjell Öberg, Gunnar Alm (auth.), Huub Schellekens (eds.)