Read e-book online Autonomic Innervation of the Heart: Role of Molecular PDF

By Riemer H.J.A. Slart, René A. Tio, Philip H. Elsinga, Markus Schwaiger

ISBN-10: 3662450739

ISBN-13: 9783662450734

ISBN-10: 3662450747

ISBN-13: 9783662450741

This publication explains intimately the aptitude worth of the hybrid modalities, SPECT-CT and PET-CT, within the imaging of cardiac innervation in quite a lot of stipulations and ailments, together with ischemic center ailment, diabetes mellitus, center failure, amyloidosis, center transplantation, and ventricular arrhythmias. Imaging of the brain-heart axis in neurodegenerative ailment and rigidity and of cardiotoxicity is additionally mentioned. the jobs of some of the on hand tracers are absolutely thought of, and person chapters handle radiopharmaceutical improvement lower than GMP, imaging physics, and kinetic modeling software program. hugely appropriate historical past details is incorporated at the autonomic apprehensive procedure of the center and its pathophysiology, and likewise destiny views are mentioned.

Awareness of the significance of autonomic innervation of the guts for the optimum administration of cardiac sufferers is starting to be, and there's an glaring desire for aim size thoughts or imaging modalities. during this context, Autonomic Innervation of the guts will be of vast curiosity to clinicians, researchers, and industry.

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Extra info for Autonomic Innervation of the Heart: Role of Molecular Imaging

Example text

5 Pathophysiology Effect of Sympathetic Innervation in Myocardial Infarction and Heart Failure .............................................................................. 6 Effect of Sympathetic Stimulation on Action Potential Duration Restitution .......................................................................................... Cardiac Parasympathetic Nervous System Dysfunction as Manifested by Baroreflex Sensitivity and Heart Rate Variability .........................................................

Lanza Goyal RK (1989) Muscarinic receptor subtypes. Physiology and clinical implications. N Engl J Med 321:1022–1029 Guyton AC, Hall JE (2006) Textbook of medical physiology. Elsevier Saunders, Philadelphia Jänig W (2006) The integrative action of the autonomic nervous system. Cambridge University Press, Cambridge, 2006 Lefkowitz RJ et al (1984) Mechanisms of membrane-receptor regulation: biochemical, physiological and clinical insights derived from studies of the adrenergic receptors. N Engl J Med 310:1570–1579 Pelc LR et al (1988) Muscarinic receptor subtypes mediating myocardial blood flow redistribution.

We will also discuss both current and future avenues of research as they relate to the fundamental understanding of how the cardiac-autonomic interface may offer itself to novel therapeutic targets for treating electrophysiologic diseases. 1 15 Implantable cardioverter defibrillator Left anterior descending artery Myocardial infarction Metaiodobenzylguanidine Nicotinamide adenine dinucleotide phosphate (NADPH) Protein kinase A Pulmonary vein isolation Sudden cardiac death Ventricular fibrillation Vagal stimulation Ventricular tachycardia Sympathetic and Parasympathetic Effects on Cellular Electrophysiology How sympathetic and parasympathetic activation differentially affect local cellular electrophysiology and how these effects translate into broader clinical disease are not entirely clear.

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Autonomic Innervation of the Heart: Role of Molecular Imaging by Riemer H.J.A. Slart, René A. Tio, Philip H. Elsinga, Markus Schwaiger

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